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Control human brain extract did not inhibit LTP. Application of HFS induced robust LTP after acute injection (asterisk, 5 μl) of control brain TBS extract (Non-AD) (n = 4) similar to vehicle-injected rats (n = 8). In contrast, injection of Aβ-containing TBS extract from the brain of another AD patient (AD) completely inhibited LTP at 3 h post-HFS (n = 5). Insets show representative traces at the times indicated. Calibration: 1.5 mV, 10 ms.
