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. 2011 Jul 20;31(29):10602–10614. doi: 10.1523/JNEUROSCI.0436-11.2011

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Copyright © 2011 the authors 0270-6474/11/3110602-13$15.00/0

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Figure 7. — Depletion of JIP3 results in the inhibition of anterograde TrkB vesicle transport. A, A 3 DIV hippocampal neuron cotransfected with EGFP and TrkB-FL-mRFP; the white box indicates the area shown in B. Scale bar, 20 μm. B, Movement of TrkB-FL-mRFP. TrkB-FL-mRFP vesicles can be transported retrogradely (down arrows), anterogradely (arrowheads), bidirectionally (up arrows). Immobile TrkB-FL-mRFP- vesicles (bold arrows) are also observed. The numbers indicate seconds. C, Kymograph of some neurites indicated in A. The kymograph of the axon and three of the dendrites for the neuron in A is shown. Images were captured every 1 s for 60 s in hippocampal neurons. Scale bar, 20 μm. D, Quantitative analysis of relative frequency of anterograde (Antero), retrograde (Retro), bidirectional (Bidir), or immobile vesicles of TrkB-FL-mRFP in siJIP3-transfected neurons The numbers of cells analyzed for each group are >60. Data shown are the mean ± SEM of three independent experiments (n = 3; *p < 0.05, vs the scramble siRNA group; one-way ANOVA).