Association between the basal CORT measure of maternal self-stress regulation and the family-to-family variations in novelty effect on working (A, B) and spatial reference (C, D) memory. A, C, At juvenility, offspring of mothers with lower postnatal basal CORT measure showed greater spatial memory enhancement induced by novelty exposure, while those with the higher CORT measure showed impairment. B, D, During mid-adulthood, this relationship was no longer detectable. *p < 0.05.