Figure 2.

Effects of overexpression of HSP70 on spatial learning and memory in transgenic mice expressing APPsw. Cognitive behavioral tests were performed, using the Morris water maze, on 12-month-old WT/WT (n = 17), WT/HSP70 (n = 9), APPsw/WT (n = 17), and APPsw/HSP70 mice (n = 16) as described in Materials and Methods. The average (4 tests) escape latency in each trial block was measured for 7 d (A), after which the mice were subjected to a transfer test in which the platform was removed. B, C, The spatial memory for a platform location was estimated by percentage search time for each quadrant (the platform had been located in the “trained” quadrant) (B) or platform crossing times (C). Values are given as mean ± SEM. **p < 0.01, *p < 0.05, versus APPsw/WT mice; ^##p < 0.01, ^#p < 0.05, versus WT/WT mice.