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Dose-dependent effect of l-DOPA on cortical excitability of the human motor cortex until 30 min following PAS. Shown is the change of the standardized mean MEP amplitudes pooled for time points until 30 min following PAS. PAS-25 and PAS-10 show maximum excitability enhancement and diminution, respectively, following medium-dose (100 mg) l-DOPA. Thus, optimal levels of PAS-induced aftereffects are observed with 100 mg of l-DOPA. LD, Low dose; MD, medium dose; HD, high dose.
