Table 2.
Hub regions in the whole cortical 2366-node network revealed by weighted degree and betweenness centrality
| Synesthetes |
Nonsynesthetes |
|||||||
|---|---|---|---|---|---|---|---|---|
| Rank | Node | Absolute centrality | Normalized centrality | Rank | Node | Absolute centrality | Normalized centrality | |
| Degree centrality | 1 | l_SMG div. 13 | 356.1 | 0.1505 | 1 | r_POS div. 6 | 249.3 | 0.1054 |
| 2 | l_SMG div. 14 | 348.6 | 0.1473 | 2 | l_SFG div. 5 | 236.6 | 0.1000 | |
| 3 | l_SMG div. 12 | 323.3 | 0.1366 | 3 | r_POS div. 12 | 236.3 | 0.0999 | |
| 4 | l_Pcu div. 15 | 319.1 | 0.1349 | 4 | r_POS div. 10 | 236.1 | 0.0998 | |
| 5 | r_PCL div. 12 | 316.3 | 0.1337 | 5 | r_CS div. 10 | 235.8 | 0.0996 | |
| 6 | l_Pcu div. 16 | 313.1 | 0.1323 | 6 | r_POS div. 9 | 235.2 | 0.0994 | |
| 7 | l_PrCG div. 27 | 312.5 | 0.1321 | 7 | l_SbCG div. 10 | 234.9 | 0.0993 | |
| 8 | l_SOS div. 3 | 309.6 | 0.1309 | 8 | r_SMG div. 21 | 234.1 | 0.0989 | |
| 9 | l_SFG div. 14 | 306.5 | 0.1295 | 9 | l_AnG div. 15 | 230.2 | 0.0973 | |
| 10 | l_PrCG div. 23 | 306.4 | 0.1295 | 10 | l_ITG div. 2 | 230.0 | 0.0972 | |
| 11 | l_MOG div. 14 | 301.9 | 0.1276 | 11 | l_AnG div. 14 | 227.8 | 0.0963 | |
| 12 | l_PrCG div. 26 | 300.8 | 0.1272 | 12 | r_POS div. 11 | 225.5 | 0.0953 | |
| 13 | r_PCL div. 10 | 300.4 | 0.1269 | 13 | l_POS div. 12 | 223.7 | 0.0945 | |
| 14 | r_PoCS div. 2 | 296.2 | 0.1252 | 14 | l_Pcun div. 17 | 223.7 | 0.0945 | |
| 15 | r_CG_M div. 6 | 296.1 | 0.1252 | 15 | r_SMG div. 20 | 223.0 | 0.0942 | |
| 16 | l_IFG_Tr div. 7 | 295.7 | 0.1250 | 16 | r_SMG div. 19 | 219.5 | 0.0928 | |
| 17 | l_PrCG div. 21 | 293.2 | 0.1239 | 17 | l_PCS div. 11 | 219.1 | 0.0926 | |
| 18 | l_SPL div. 20 | 290.5 | 0.1228 | 18 | r_SOG div. 10 | 217.9 | 0.0921 | |
| 19 | l_PrCG div. 22 | 289.6 | 0.1224 | 19 | r_OTS_m div. 9 | 217.8 | 0.0920 | |
| 20 | l_PCL div. 15 | 289.4 | 0.1223 | 20 | l_SPL div. 21 | 217.3 | 0.0918 | |
| Betweenness centrality | 1 | l_SMG div. 13 | 8050.9 | 0.0029 | 1 | r_POS div. 6 | 6090.8 | 0.0022 |
| 2 | l_CS div. 30 | 6048.4 | 0.0022 | 2 | l_ITG div. 2 | 5900.9 | 0.0021 | |
| 3 | l_SOS div. 3 | 5956.1 | 0.0021 | 3 | r_SMG div. 19 | 5783.9 | 0.0021 | |
| 4 | r_PCL div. 10 | 5954.9 | 0.0021 | 4 | l_AnG div. 15 | 5739.1 | 0.0021 | |
| 5 | r_TTG div. 2 | 5736.6 | 0.0021 | 5 | r_CS div. 10 | 5519.2 | 0.0020 | |
| 6 | l_PrCG div. 26 | 5592.5 | 0.0020 | 6 | l_Pcun div. 17 | 5286.1 | 0.0019 | |
| 7 | l_PrCG div. 23 | 5382.0 | 0.0019 | 7 | l_PoCG div. 1 | 5147.1 | 0.0018 | |
| 8 | l_PrCG div. 27 | 5339.9 | 0.0019 | 8 | l_MOG div. 14 | 5131.1 | 0.0018 | |
| 9 | l_OTS_l div. 1 | 5294.8 | 0.0019 | 9 | r_SMG div. 21 | 5071.6 | 0.0018 | |
| 10 | l_PoCS div. 28 | 5291.8 | 0.0019 | 10 | r_POS div. 8 | 4937.1 | 0.0018 | |
| 11 | r_PCL div. 12 | 5245.1 | 0.0019 | 11 | r_CG_M div. 3 | 4892.2 | 0.0018 | |
| 12 | l_SFG div. 14 | 5173.1 | 0.0019 | 12 | l_SOG div. 1 | 4887.3 | 0.0017 | |
| 13 | l_AOS div. 2 | 5117.3 | 0.0018 | 13 | l_ITG div. 3 | 4879.3 | 0.0017 | |
| 14 | l_MOG div. 14 | 5091.9 | 0.0018 | 14 | r_SMG div. 20 | 4853.5 | 0.0017 | |
| 15 | l_SMG div. 12 | 5081.1 | 0.0018 | 15 | l_IFS div. 5 | 4772.8 | 0.0017 | |
| 16 | l_SMG div. 14 | 5069.0 | 0.0018 | 16 | r_IFS div. 10 | 4747.1 | 0.0017 | |
| 17 | l_PrCG div. 22 | 5060.2 | 0.0018 | 17 | l_POS div. 9 | 4720.2 | 0.0017 | |
| 18 | l_STS div. 15 | 5025.1 | 0.0018 | 18 | r_SbCG div. 8 | 4675.4 | 0.0017 | |
| 19 | r_PoCS div. 2 | 4907.9 | 0.0018 | 19 | l_SbCG div. 10 | 4646.9 | 0.0017 | |
| 20 | l_IFG_Tr div. 7 | 4905.6 | 0.0018 | 20 | l_SMG div. 14 | 4628.9 | 0.0017 | |
Shown are the 20 largest hub regions. Note the significantly higher degree centrality scores of the 20 largest hubs in synesthetes compared with nonsynesthetes (two-sample t test, p ≪ 0.0001). Although synesthetes showed Increased betweenness centrality, this difference shows only a statistical trend toward significance (p = 0.069). Normalized degree centrality is computed by dividing the absolute degree by the number of nodes (2366) in the network. Normalized betweenness centrality is computed by dividing the absolute betweenness by [(1/2) × (2366 − 1) × (2366 − 2)]. For the code of the structural parcellation labels, see supplemental Table S2 (available at www.jneurosci.org as supplemental material). div., Division.