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. 2011 Mar 23;31(12):4544–4554. doi: 10.1523/JNEUROSCI.5394-10.2011

Figure 5.

Figure 5.

l-Dopa attenuated motor deficits in 6-OHDA-treated rats. l-Dopa (6 mg/kg plus benserazide 15 mg/kg, i.p.) increased motor performance in the bar (A), drag (B), and elevated body swing (C) test. All measures were performed before and 10, 60, 120, and 180 min after l-dopa or vehicle administration. Data are means ± SEM of five determinations per group and are expressed as absolute values (seconds (sec), steps, and swings, respectively). Statistical results: A, Left, Effect of treatment (F(1,4) = 17.53, p = 0.0138), time (F(4,32) = 13.05, p < 0.0001), and time × treatment interaction (F(4,32) = 13.46, p < 0.0001). Right, Effect of treatment (F(1,4) = 165.08, p = 0.0002), time (F(4,32) = 26.68, p < 0.0001), and time × treatment interaction (F(4,32) = 16.82, p < 0.0001). B, Left, Effect of treatment (F(1,4) = 290.89, p < 0.0001), time (F(4,32) = 13.11, p < 0.0001), and time × treatment interaction (F(4,32) = 11.80, p < 0.0001). Right, Effect of treatment (F(1,4) = 292.67, p = 0.0002), time (F(4,32) = 16.37, p < 0.0001), and time × treatment interaction (F(4,32) = 12.92, p < 0.0001). C, Left, Effect of treatment (F(1,4) = 41.97, p = 0.0029), time (F(4,32) = 9.35, p < 0.0001), and time × treatment interaction (F(4,32) = 6.98, p = 0.0004). Right, Effect of treatment (F(1,4) = 23.12, p = 0.0086), time (F(4,32) = 12.09, p < 0.0001), and time × treatment interaction (F(4,32) = 9.82, p < 0.0001). *p < 0.05, **p < 0.01 different from control; °p < 0.05, °°p < 0.01 different from vehicle (RM ANOVA followed by contrast analysis and the sequentially rejective Bonferroni's test for multiple comparisons).