Figure 6.
l-Dopa partially restored M1 output in 6-OHDA-treated rats. l-Dopa (6 mg/kg plus benserazide, 15 mg/kg, i.p.) affected the size (in mm2) of unexcitable (A), vibrissa (B), caudal (C), and rostral forelimb (D) areas, the threshold current (in μA) in vibrissa (E) and forelimb (F) areas, and the frequency (in percentage of total movements) of contralateral (G) and distal (H) forelimb movements. All measures were performed in control and 6-OHDA rats at 15 and 60 d after lesion. Data are means ± SEM of five determinations per group. Statistical results: A, Effect of treatment (F(1,4) = 28.34, p = 0.0060), time (F(2,16) = 53.07, p < 0.0001), and time × treatment interaction (F(2,16) = 19.61, p < 0.0001). B, Effect of treatment (F(1,4) = 11.88, p = 0.0261), time (F(2,16) = 11.42, p = 0.0008), and time × treatment interaction (F(2,16) = 9.56, p < 0.0019). C, Effect of treatment (F(1,4) = 7.89, p = 0.0483), time (F(2,16) = 7.57, p = 0.0049), and time × treatment interaction (F(2,16) = 4.58, p = 0.0267). D, Effect of time (F(2,16) = 46.81, p < 0.0001) but not treatment (F(1,4) = 2.57, p = 0.18) or time × treatment interaction (F(2,16) = 0.85, p = 0.45). E, Effect of time (F(2,16) = 33.35, p < 0.0001) but not treatment (F(1,4) = 5.34, p = 0.08) or time × treatment interaction (F(2,16) = 3.26, p = 0.06). F, Effect of time (F(2,16) = 28.16, p < 0.0001) but not treatment (F(1,4) = 1.67, p = 0.27) or time × treatment interaction (F(2,16) = 3.53, p = 0.05). G, Effect of time (F(2,16) = 8.46, p = 0.0031) but not treatment (F(1,4) = 0.06, p = 0.81) or time × treatment interaction (F(2,16) = 3.32, p = 0.06). H, Effect of treatment (F(1,4) = 36.06, p = 0.0039) and time (F(2,16) = 9.64, p = 0.0018) but not time × treatment interaction (F(2,16) = 1.85, p = 0.19). *p < 0.05, **p < 0.01 different from control without and with l-dopa; °p < 0.05, °°p < 0.01 different from vehicle (RM ANOVA followed by contrast analysis and the sequentially rejective Bonferroni's test for multiple comparisons).