A–C, The effects of vehicle (ACSF) or (S)-3,4-DCPG (10 μm referred to the microdialysis fiber, 30 min, n = 10) perfusion into the CeA on release of 5-HT (A), glutamate (B), and GABA (C) in rats receiving saline (Nor) or carrageenan (Carr) into the hindpaw. The values of extracellular 5-HT, glutamate, and GABA level in the CeA were expressed as a percentage of the mean basal value and were measured before and after ACSF or (S)-3,4-DCPG perfusion into the CeA as indicated by the bar. Each point represents the mean ± SEM of 10 animals per group; *p < 0.05, **p < 0.01, significant differences vs Carr/ACSF (two-way ANOVA/Newman–Keuls).