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. 2011 Mar 23;31(12):4687–4697. doi: 10.1523/JNEUROSCI.2938-10.2011

Figure 3.

Figure 3.

Thermal withdrawal latency (in seconds) was measured 30 min after the injection of saline (150 μl of saline, Nor) or carrageenan (1%, 150 μl, Carr) into the hindpaw. A shows the effect of ACSF or (S)-3,4-DCPG (10 μm referred to the microdialysis fiber, 30 min, n = 10) perfused into the CeA, as indicated by the bar. B shows the effect of ACSF or three doses of (S)-3,4-DCPG (1, 10, and 100 μm referred to the microdialysis fiber, 30 min, n = 10 for each dose) perfused into the CeA, as indicated by the bar, in rats receiving carrageenan. Carrageenan injection induced a reduction in thermal withdrawal latency with a peak at 240 min in rats receiving ACSF into the probe. Thermal withdrawal latency significantly increased after (S)-3,4-DCPG (1, 10, and 100 μm referred to the microdialysis fiber, 30 min, n = 10) in the rats receiving the peripheral injection of carrageenan into the hindpaw. Normal rats receiving (S)-3,4-DCPG (10 μm referred to the microdialysis fiber, 30 min, n = 10) showed no significant changes in thermal withdrawal latency. Significant differences *vs Nor/ACSF, % vs Carr/ACSF. p values < 0.05 or 0.01 have been indicated by a single or double symbol, respectively (two-way ANOVA/Newman–Keuls).