Figure 4.

Thermal withdrawal latency (in seconds) was measured 30 min after the injection of saline (150 μl saline, Nor) or carrageenan (1%, 150 μl, Carr) into the hindpaw. A shows the effect of ACSF, (S)-3,4-DCPG (10 μm referred to the microdialysis fiber, 30 min, n = 10) or the latter in combination with MSOP (10 mm referred to the microdialysis fiber, 30 min, n = 10) perfused into the CeA, as indicated by the bar, in rats receiving carrageenan. B shows the effect of ACSF or MSOP (10 mm referred to the microdialysis fiber, 30 min, n = 10) perfused into the CeA, as indicated by the bar, in rats receiving saline or carrageenan. Significant differences *vs Nor/ACSF, ^% vs Carr/ACSF, and ^#vs Carr/DCPG. p values < 0.05 or 0.01 have been indicated by a single or double symbol, respectively (two-way ANOVA/Newman–Keuls).