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. 2011 Jun 15;31(24):9055–9066. doi: 10.1523/JNEUROSCI.0185-11.2011

Figure 5.

Figure 5.

The effect of expression of Munc18-1 mutants on the fusion pore dwell-time. A, Representative reversible transient fusion events, observed in the Im trace. B, The average fusion pore dwell-time increased significantly in cells transfected with Munc18-1 P242S and E466K, compared with controls (p = 0.04 and 0.005, respectively). Cells transfected with Munc18-1 R39C exhibited no differences in the average pore dwell-time, compared with cells transfected with Munc18-1 WT. Numbers above the error bars indicate the number of analyzed patches (samples in statistical analysis) and reversible steps (in parentheses).