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. 2011 Jun 15;31(24):8786–8802. doi: 10.1523/JNEUROSCI.3257-10.2011

Figure 3.

Figure 3.

Expression of CREB-Y134F enhances memory formation. A, B, Social recognition test. A, Recognition index. *p < 0.05. B, Investigation time. Thirty minutes or 2 h after the first exposure, WT and Y134F mice showed a significant reduction in investigation time (a paired t test, p < 0.05). In contrast, at 24 h after the first exposure, Y134F, but not WT, mice showed a significant reduction in investigation time (WT, p > 0.05; A and C, p < 0.05). *p < 0.05, compared with the first exposure. Data show 30 min STM (WT, n = 13; A, n = 14; C, n = 13), 2 h STM (WT, n = 25; A, n = 11; C, n = 11), and 24 h LTM (WT, n = 24; A, n = 8; C, n = 12). C, Contextual fear-conditioning test. Data show 30 min STM (WT, n = 22; A, n = 12; C, n = 15), 2 h STM (WT, n = 18; A, n = 11; C, n = 14), and 24 h LTM (WT, n = 44; A, n = 17; C, n = 20). *p < 0.05. D, Contextual discrimination test. Data show 1 d (WT-CXT-S, n = 10; WT-CXT-D, n = 11; Y134F-C-CXT-S, n = 13; Y134F-C-CXT-D, n = 12) or 1 month (WT-CXT-S, n = 18; WT-CXT-D, n = 10; Y134F-C-CXT-S, n = 17; Y134F-C-CXT-D, n = 12) totals. *p < 0.05. E–G, Morris water maze test. WT, n = 22; A, n = 12; C, n = 17. *p < 0.05, compared with the other three quadrants (a paired t test); #p < 0.05. H, Passive avoidance test. Data show 2 h (WT, n = 13; C, n = 13) and 24 h (WT, n = 14; C, n = 12) totals. *p < 0.05. Error bars represent SEM.