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Inactivation of ERK2 results in more astrocytes within the cerebral cortex. Immunohistochemistry with GFAP, a marker for astrocyte, reveals that GFAP immunoreactivity is increased in the cortices of Erk2 CKO mice compared with controls at 13 weeks of age. Note that GFAP+ cells seem to be more abundant in outer layers than inner layers of cortices in Erk2 CKO mice. Scale bar, 100 μm.
