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Myelination was reduced on quiescent astrocytes. A–C, Myelinating cultures were plated on PLL-As (A) or TnC-As (B). PLL-As were treated with 2 ng/ml CNTF from day 12 onward (C). D, Myelination was significantly higher on PLL-As compared with those plated on TnC-As. Treatment of cultures on PLL-As with CNTF resulted in a significant increase in myelination compared with untreated PLL-As. E, Neurite density was similar in all conditions. *p < 0.05.
