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. 2011 Jun 8;31(23):8625–8633. doi: 10.1523/JNEUROSCI.1020-11.2011

Figure 3.

Figure 3.

Effects of DA receptor manipulations in the medial PFC on probabilistic discounting. Data are plotted in terms of percentage choice of the large/risky lever during free-choice trials by probability block (x-axis). Symbols represent mean + SEM. Gray stars denote a significant main effect (saline vs high dose, p < 0.05). Black stars denote a significant difference (p < 0.05) between treatment conditions during a particular probability block main effect. A, Infusions of the 1.0 μg dose of D1 antagonist SCH23390 accelerated probabilistic discounting, reducing risky choice. B, In contrast, infusions of the 1.0 μg dose of the D2 antagonist eticlopride retarded discounting and increased risky choice. C, The D1 agonist SKF81297 induced a slight, nonsignificant increase in risky choice. D, Infusions of the 10 μg dose of the D2 agonist quinpirole abolished discounting, decreasing risky choice during the initial block and increasing choice during the final block.

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