Table 1.
Model parameters
| LE | ρ | CS (pF) | GS (nS) | GD (nS) | gNa (S/cm2) | gK (S/cm2) | τ̄n (ms) | gKD (mS/cm2) | tfac | gKA (mS/cm2) | τa (ms) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phasic impedance | ||||||||||||
| PI1 | 0.68 | 3.71 | 195.81 | 45.44 | 10.70 | — | — | — | 1.51 | 1.06 | — | — |
| PI2 | 0.95 | 6.99 | 90.93 | 9.42 | 65.80 | — | — | — | 5.13 | 0.84 | — | — |
| PI3 | 0.67 | 1.76 | 127.77 | 27.26 | 6.30 | — | — | — | 10.00 | 1.10 | — | — |
| Mean | 0.77 | 4.15 | 138.17 | 27.37 | 27.60 | — | — | — | 5.55 | 1.00 | — | — |
| SD | 0.16 | 2.64 | 53.21 | 18.01 | 33.16 | — | — | — | 4.26 | 0.14 | — | — |
| Tonic | ||||||||||||
| T1 | 1.05 | 6.22 | 84.28 | 15.53 | 3.65 | 0.074 | 0.016 | 7.2 | — | — | 0.073 | 58.58 |
| T2 | 0.67 | 6.86 | 93.13 | 36.56 | 5.99 | 0.108 | 0.013 | 3.1 | — | — | 0.123 | 51.08 |
| T3 | 0.98 | 7.89 | 118.12 | 38.10 | 12.97 | 0.098 | 0.013 | 4.1 | — | — | 0.105 | 44.32 |
| T4 | 1.22 | 8.46 | 75.76 | 32.50 | 8.05 | 0.125 | 0.009 | 2.9 | — | — | 0.106 | 46.04 |
| T5 | 1.50 | 9.32 | 111.47 | 30.84 | 1.60 | 0.090 | 0.018 | 6.4 | — | — | 0.240 | 37.71 |
| T6 | 0.91 | 6.41 | 62.80 | 17.74 | 4.34 | 0.106 | 0.010 | 6.0 | — | — | 0.171 | 65.18 |
| T7 | 0.75 | 5.14 | 100.24 | 23.53 | 11.10 | 0.112 | 0.015 | 2.6 | — | — | 0.156 | 42.17 |
| Mean | 1.01 | 7.19 | 92.26 | 27.83 | 6.81 | 0.102 | 0.013 | 4.6 | — | — | 0.139 | 49.30 |
| SD | 0.28 | 1.44 | 19.60 | 8.98 | 4.12 | 0.017 | 0.003 | 1.9 | — | — | 0.055 | 9.68 |
| Phasic | ||||||||||||
| P1 | 1.66 | 4.47 | 39.39 | 35.88 | 8.75 | 0.102 | 0.013 | 4.6 | 3.43 | 1 | — | — |
| P2 | 0.86 | 4.68 | 27.14 | 52.02 | 27.84 | 0.102 | 0.013 | 4.6 | 1.49 | 1 | — | — |
| P3 | 0.79 | 2.54 | 32.32 | 18.97 | 12.58 | 0.102 | 0.013 | 4.6 | 2.71 | 1 | — | — |
| P4 | 1.42 | 8.84 | 38.76 | 6.85 | 3.35 | 0.102 | 0.013 | 4.6 | 4.74 | 1 | — | — |
| P5 | 1.05 | 2.22 | 23.28 | 38.80 | 20.09 | 0.102 | 0.013 | 4.6 | 0.71 | 1 | — | — |
| P6 | 0.73 | 5.21 | 22.20 | 34.23 | 2.24 | 0.102 | 0.013 | 4.6 | 1.66 | 1 | — | — |
| P7 | 1.41 | 9.04 | 41.64 | 35.03 | 30.84 | 0.102 | 0.013 | 4.6 | 4.40 | 1 | — | — |
| P8 | 0.75 | 6.20 | 46.60 | 24.00 | 17.98 | 0.102 | 0.013 | 4.6 | 2.57 | 1 | — | — |
| P9 | 0.70 | 6.13 | 12.26 | 27.85 | 13.26 | 0.102 | 0.013 | 4.6 | 7.08 | 1 | — | — |
| P10 | 0.73 | 9.45 | 36.60 | 42.70 | 4.45 | 0.102 | 0.013 | 4.6 | 1.23 | 1 | — | — |
| P11 | 1.09 | 9.73 | 56.85 | 4.41 | 12.86 | 0.102 | 0.013 | 4.6 | 8.19 | 1 | — | — |
| P12 | 1.17 | 2.26 | 48.82 | 20.29 | 43.94 | 0.102 | 0.013 | 4.6 | 1.97 | 1 | — | — |
| P13 | 1.15 | 2.48 | 21.75 | 18.46 | 9.89 | 0.102 | 0.013 | 4.6 | 1.96 | 1 | — | — |
| P14 | 0.77 | 5.18 | 61.79 | 13.88 | 20.67 | 0.102 | 0.013 | 4.6 | 1.73 | 1 | — | — |
| P15 | 0.88 | 8.65 | 74.77 | 29.45 | 7.76 | 0.102 | 0.013 | 4.6 | 1.86 | 1 | — | — |
| P16 | 0.81 | 8.75 | 37.68 | 37.71 | 7.91 | 0.102 | 0.013 | 4.6 | 0.85 | 1 | — | — |
| P17 | 1.10 | 9.21 | 22.99 | 43.65 | 12.20 | 0.102 | 0.013 | 4.6 | 0.75 | 1 | — | — |
| Mean | 1.00 | 6.18 | 37.93 | 28.48 | 15.09 | 0.102 | 0.013 | 4.6 | 2.78 | 1 | — | — |
| SD | 0.29 | 2.80 | 16.30 | 13.34 | 10.95 | — | — | — | 2.17 | — | — | — |
Parameters for the Hodgkin–Huxley-type models of phasic and tonic 2°VNs (see details in Materials and Methods). For both neuronal types, time-domain models have been fitted to frequency–current (f–I) and membrane potential decay responses (cells T1–T7 and P1–P17). In addition, frequency-domain models have been fitted to impedance magnitude measurements of three phasic neurons (cells PI1–PI3). The mean values (mean) and standard deviations (SD) are indicated for each fit method and cell type.