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. 2011 Aug 3;31(31):11200–11207. doi: 10.1523/JNEUROSCI.2211-11.2011

Figure 1.

Figure 1.

a, b, Mean (±SEM) fold change in Arc mRNA relative to both untrained home cage controls and GAPDH. There was a significant increase in Arc mRNA expression in DH (a) and VH (b) after trace and contextual, but not delay, fear conditioning. *p < 0.05. c, Experiment design. d, Mean (±SEM) fold change in Arc mRNA relative to both untrained home cage controls and GAPDH. Trace fear conditioning enhanced Arc mRNA levels in DH and VH. *p < 0.05. e, f, Mean (±SEM) percentage increase in Arc protein expression relative to untrained home cage controls and actin. Infusions of Arc antisense ODNs into DH (e) or VH (f) attenuated the learning-induced enhancement of Arc protein in a regionally specific manner. *p < 0.05. g, h, Representative blots for subjects with cannula targeted at DH (g) or VH (h). HC, Home cage controls; SCR, scrambled ODN infusion; AS, Arc antisense ODN infusion.