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. 2011 Aug 3;31(31):11200–11207. doi: 10.1523/JNEUROSCI.2211-11.2011

Figure 2.

Figure 2.

a–c, Mean (±SEM) percentage freezing during training in the trace conditioning paradigm. Infusions of Arc antisense or scrambled ODNs into the DH or VH had no effect on behavior during the ITI (a), CS (b) or the trace interval (c). d–f, Mean (±SEM) percentage freezing during the testing session 48 h after training. Pretraining infusions of Arc antisense ODNs into DH or VH impaired conditioned freezing during the ITI (d), CS (e), and trace interval (f). *p < 0.05. g, Pretraining infusions of Arc antisense ODNs into DH or VH impaired conditioned freezing during the context test. *p < 0.05. h, i, Representative photomicrograph of accurate cannula placement in DH (h) or VH (i). j, k, Infusions of Arc antisense or scrambled ODNs into VH before delay fear conditioning had no effect on freezing behavior during training. l, m, Infusions of Arc antisense ODNs into VH before delay conditioning had no effect on freezing to the CS during subsequent testing (l), but significantly impaired conditioned freezing during the first 3 min of the context test (m). *p < 0.05. SCR, Scrambled ODN infusion; Arc AS, Arc antisense ODN infusion.