Figure 5.

Inflammatory pain in CNGA3^−/− mice. A, B, Formalin test. A, Time course of licking behavior of the formalin-injected hindpaw. B, Sum of paw-licking time in phase 1 (0–10 min) and phase 2 (11–60 min) demonstrating increased licking behavior in CNGA3^−/− mice. C, Zymosan-induced mechanical hyperalgesia. Time course of paw withdrawal latency time after mechanical stimulation demonstrates increased mechanical hyperalgesia in CNGA3^−/− mice after zymosan injection. All data are presented as mean ± SEM. *p < 0.05, comparing CNGA3^−/− and WT mice. n = 7–9 per group.