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cGMP-induced nociceptive behavior in CNGA3−/− mice. A–C, Time course of mechanical allodynia induced by intrathecal administration of the cGMP analogs 8-pCPT-cGMP (20 nmol; A) and Rp-8-pCPT-cGMPS (20 nmol; B), or of saline (C). Data indicate that the extent of cGMP-induced allodynia is increased in CNGA3−/− mice. All data are presented as mean ± SEM. *p < 0.05, comparing CNGA3−/− and WT mice. n = 6–8 per group.
