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Natriuretic peptide and NO-induced nociceptive behavior in CNGA3−/− mice. A, B, Time course of mechanical allodynia induced by intrathecal administration of CNP (200 ng; A) or NOC-5 (NO donor, 10 μg; B). Data indicate that the extent of NO-induced allodynia, but not that of CNP-induced allodynia, is increased in CNGA3−/− mice. All data are presented as mean ± SEM. *p < 0.05, comparing CNGA3−/− and WT mice. n = 7–9 per group.
