Figure 3.

Segregation of rats submitted to the SSP into responder (depressive) and nonresponder (nondepressive) animal populations. a, Based on the corticosterone concentrations measured in CMS rats, the highest corticosterone level (43.94 ng/ml) was set as a cutoff for splitting the SSP animal population into two subpopulations: those with values of >43.94 ng/ml, named responder rats (n = 20) and those with values of <43.94 ng/ml, called nonresponder rats (n = 28). b, Distinct serum BDNF concentrations between R, NR, and C (n = 15) animals. c, Evaluation of depression-like profile by the FST and the sweet water consumption of R, NR, and C animals (n = 8–12). Data presented as box plots show the 25th and 75th percentiles. The bars in the boxes represent the medians. *p < 0.05 versus C rats; ^†p < 0.05 versus NR rats.