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. 2011 Jan 12;31(2):501–511. doi: 10.1523/JNEUROSCI.2608-10.2011

Figure 5.

Figure 5.

Presynaptic stimulation-induced incorporation of GluR2 receptors abolished spermine-dependent postsynaptic facilitation. A, When spermine was included in the pipette solution, the amplitude of the synaptic current at +40 mV was attenuated, indicating the presence of GluR2-lacking AMPA receptors at the parallel fiber-to-stellate cell synapse. High-frequency presynaptic stimulation (HFS) induced an increase in the EPSC amplitude at +40 mV and a decrease at −60 mV. HFS also abolished postsynaptic paired-pulse facilitation that was observed at the naive synapse (A2/A1). B, In the absence of spermine, the synaptic current exhibited a linear I–V relationship even before stimulation. HFS did not alter the paired-pulse ratio. C, Summary of HFS-induced changes in rectification index (n = 6; *p < 0.01) and paired-pulse ratio (n = 6; *p < 0.05) in the presence of intracellular spermine. D, Summary of rectification index and paired-pulse ratio changes in the absence of intracellular spermine (n = 5). Error bars indicate SEM.