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. 2011 Jan 12;31(2):501–511. doi: 10.1523/JNEUROSCI.2608-10.2011

Figure 6.

Figure 6.

Changes in postsynaptic facilitation altered the pattern of AP firing evoked by paired inputs. A, Test of the ability of paired conductances approximating the prestimulation (GluR2-lacking) and post PF-stimulation (GluR2-containing) waveforms to evoke action potentials in stellate cells. Left panel, The sample AP response is shown in the raster plot at the unitary conductance (arrows indicate the time of paired conductance application). Right panel, Prestimulation, GluR2-lacking (GluR2-) unitary paired conductance evokes significantly more APs after the second pulse (n = 9; **p < 0.005). B, Example of a doublet and a single AP evoked by paired prestimulation and poststimulation template at double the unitary amplitude. Doublet APs evoked by the same stimulation train are marked with red symbols in the raster plot. C, An example plot of AP probability demonstrating the doublet detection window (arrows indicate the time of paired conductance injection; AP probability within 5 ms bins). D, The presence of postsynaptic facilitation enhances doublet AP probability for the GluR2-lacking template (n = 7; *p < 0.05, **p < 0.001). Error bars indicate SEM.