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. 2011 Mar 16;31(11):4194–4203. doi: 10.1523/JNEUROSCI.5239-10.2011

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Copyright © 2011 the authors 0270-6474/11/314194-10$15.00/0

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Figure 3. — Withdrawal from repeated cocaine exposure inhibits the induction of PP-LFS-LTD in the NAc shell MSNs. A, B, Summary of experiments showing the induction of PP-LFS-LTD (50 ms interstimulus interval, 1 Hz/15 min, in the presence of d-APV 50 μm) in the shell (A) and core (B) MSNs from saline (SAL)- or cocaine (COC)-treated mice on WD14. C, D, Summary of experiments showing the effects of mGluR1 antagonist LY367385 (C) and mGluR5 antagonist MPEP (D) on the induction of PP-LFS-LTD in the NAc shell in slices from SAL- or COC-treated mice. Representative traces of EPSCs were taken at the time indicated by number. Horizontal bar denotes the period of delivery of PP-LFS. Dashed line indicates baseline level.