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. 2011 Mar 16;31(11):4137–4147. doi: 10.1523/JNEUROSCI.2592-10.2011

Figure 6.

Figure 6.

Regenerating axons grow into the grafted nerves of repaired spinal cords filled with BDNF- and spermidine-expressing macrophages at 14 d. A, B, Longitudinal sections of 6 d (A) and 14 d (B) repaired spinal cords are positioned so that the left side of the tissue is rostral to the lesion site. Sections were stained for GAP-43. Individual grafted nerves are indicated by asterisks. Scale bar, 1 mm. C–E, Many GAP-43-positive axons grow alone with Iba1-positive macrophages (C), BDNF-expressing macrophage (D), and spermidine-expressing macrophages (E) within the grafted nerves of repaired spinal cords at 14 d. Scale bar, 100 μm. F, Schematic representation of the recombinant Ad-GFP used to trace neurons. Two weeks after repair, Ad-GFP was injected into T9 of repaired spinal cords. G–J, There were several GFP-positive regenerating axons found along the grafted nerves and approaching the rostral stumps. Scale bar, 100 μm. K, L, Three months after repair, CTB-HRP was injected into T7 of repaired spinal cords. CTB-HRP-positive neurons were found in the dorsal horns of the lumbar areas of repaired spinal cords. Scale bar, 100 μm.