Figure 2.

Locomotor hyperactivity was induced after Co-wire was implanted. a, Cobalt-implanted mice exhibited higher locomotor activity in an open field compared with nonepileptic controls. b, The example of locomotor patterns of the cobalt group and control group during the first 5 min (5 min) and last 5 min (60 min) of a 60 min recording. c, Cobalt-implanted mice showed increased total distance moved during 60 min. d, Center exploration was decreased in cobalt-implanted mice during first 5 min of the open-field test. e, The cobalt group of mice showed stereotypic circling, repetitive movement in the same direction, while the control mice were exploratory. *p < 0.05, ***p < 0.001. Data represent means ± SEM.