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. 2019 Jun 28;13(6):e0007537. doi: 10.1371/journal.pntd.0007537

Fig 5. TRIM56 inhibits ZIKV RNA replication.

Fig 5

(A) HEK293-T3Y cells with or without expression of FH-TRIM56 were infected by ZIKV MR766 strain (MOI = 1) for the indicated times, followed by qPCR analysis of intracellular viral RNA levels. NS, not significant. (B) Intracellular viral RNA levels in HEK293-T3Y cells with or without expression of FH-TRIM56 that were infected by ZIKV PRVABC59 strain at indicated MOIs for 72 h. ND, non-detectable. (C) Intracellular viral RNA levels in HEK293 cells stably transduced with empty vector (Bsr), Flag-T56-WT, Flag-T56-Mut N, or Flag-T56-AA that were infected by ZIKV MR766 strain (MOI = 1) for 72 h. (D) Intracellular viral RNA levels in HeLa-shCtrl and HeLa-shT56 cells infected by ZIKV MR766 strain for 72 h. Results shown in panel B were representative of two independent experiments. Results in the rest panels were representative of three independent experiments. One-way ANOVA test (in panel C) or Student t-test (in the rest panels), *P<0.05, **P<0.01, ***P<0.001.