Figure 7.

Schematic representation of the putative functional implications of the FGF-2/FGFR1/Anosmin-1 system in MS. A, In active lesions (where remyelination is possible), there is an increment in the density of FGF-2 expressing macrophages and FGFR1⁺ OPCs, whereas Anosmin-1 is absent. B, In contrast, in chronic-active lesions (where remyelination rarely exists and is mainly restricted to the periplaque), the molecular environment is drastically different: FGF-2 expression is limited to the macrophages/microglia in the periplaque, probably attracting FGFR1⁺ OPCs toward the lesion; on the contrary, the expression of Anosmin-1 is widespread throughout the core of the lesion and may be preventing remyelination.