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Ablating tagged neurons. a, DT (n = 4) but not PBS (n = 6) efficiently ablated DTR-expressing cells in the DG (scale bar, 10 μm). b–d, Consistent with this, DT treatment reduced overall numbers of doublecortin+ (DCX; scale bar, 150 μm) (b), nestin+ (scale bar, 10 μm) (c), and calretinin+ (scale bar, 10 μm) (d) cells in the DG of 2xTg mice. Mo, Molecular layer; GCL, granule cell layer. *p < 0.05.
