Figure 8.

Pretraining ablation of adult-generated neurons does not prevent the formation of a new contextual fear memory. a, Mice were trained in context A after DT-induced ablation of adult-generated neurons. Contextual memory was assessed in contexts A–C 1 week later. b, c, During training, CTR (n = 13) and 2xTg (n = 14) mice exhibited similar response to shock (b) and freezing (c) levels before and after shock delivery. d, e, After DT treatment, both CTR and 2xTg mice discriminated between contexts A and B (d), and the degree of discrimination did not differ (e). f, g, Freezing in a dissimilar context (f) and tone fear (g) were equivalent in CTR and 2xTg mice. *p < 0.05.