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. 2011 Jan 26;31(4):1313–1322. doi: 10.1523/JNEUROSCI.4060-10.2011

Figure 1.

Figure 1.

Actions of MOR agonist DAMGO on presynaptic inhibition of monosynaptic Aδ- and C-fiber EPSCs. A, Time course of the reversible inhibition of DAMGO at different concentrations on evoked monosynaptic Aδ-fiber EPSCs. Right, Original traces taken from the indicated time points before (1), during (2), and after (3) the application of 1 μm DAMGO. B, Representative time course of the inhibitory effect of DAMGO (100 nm) on monosynaptic C-fiber EPSCs. Inset shows the corresponding original traces. C, Differential inhibition by DAMGO (100 nm) on Aδ- and C-fiber EPSCs recorded simultaneously from the same neuron. Inset, The corresponding original traces with Aδ- and C-fiber peaks. D, Dose–response curves of presynaptic DAMGO inhibition on monosynaptic C- (black circles) and Aδ-fiber (white circles)-evoked EPSCs. Numbers in parenthesis indicate the numbers of neurons tested. IC50 = 157 nm for C-fiber EPSCs and IC50 = 215 nm for Aδ-fiber EPSCs. Inset, The characterization of monosynaptic Aδ- and C-fiber-evoked EPSCs. Ten traces superimposed show a jitter of <10% of the response latency and no failures. Calibration: A, D (inset), 100 pA, 5 ms; B, C, 100 pA, 10 ms.