Table 1.

Experimental designs for Experiments 1, 2, and 3

Experiment/group	Day 1	Day 2	Day 3	Day 4	Day 5
Experiment 1	Conditioning	Extinction	Test
Vehicle	5 CS+	6 CS− → Vehicle	CS−	—	—
FGF2	5 CS+	6 CS− → FGF2	CS−	—	—
FGF2 No Extinction	5 CS+	— → FGF2	CS−	—	—
Experiment 2	Conditioning	Extinction day 1	Extinction day 2	Test
Vehicle	5 CS+	12 CS− → Vehicle	12 CS−	CS− Context A/B	—
FGF2	5 CS+	6 CS− → FGF2	—	CS− Context A/B	—
Experiment 3	Conditioning	Extinction day 1	Extinction day 2	Reinstatement	Test
Vehicle Reinstate	5 CS+	12 CS− → Vehicle	12 CS−	Unsignaled US	CS−
FGF2 Reinstate	5 CS+	6 CS− → FGF2	—	Unsignaled US	CS−
Vehicle No Reinstate	5 CS+	12 CS− → Vehicle	12 CS−	—	CS−