Figure 10.
Absence of hippocampal LTP in the CA1 in pro-aggregant TauRD mice. A, Field recordings in the CA1 region of the hippocampus did not reveal any differences in input/output properties (p > 0.05 for all comparisons). B, PPF, a form of short-term plasticity, was altered at the 10 and 20 ms interval in anti-aggregant mice (green bars) compared with control (blue bars; *p < 0.05). C, LTP induced by a single tetanus revealed differences between the genotypes (**p < 0.01). Whereas slices of control mice developed an LTP that slowly returned to baseline during the 4 h recording period, pro-aggregant TauRD mice were completely devoid of LTP. The only potentiation obtained was PTP 1 min after tetanization. Anti-aggregant TauRD mice developed a robust LTP that was even more pronounced than that of controls. Anti-aggr., Anti-aggregant; Pro-aggr., pro-aggregant; ISI, interstimulus interval; TBS, theta burst stimulation.