Figure 7.
Reduced short-term plasticity at the mossy fiber–CA3 synapse in pro-aggregant TauRD mice. A, Amplitudes of mossy fiber (mf) fEPSPs are plotted as a function of stimulus intensity to determine input–output relationships. B, The top trace depicts mossy fiber fEPSPs in response to four stimuli at 20 Hz recorded from a control slice. The diagram below displays the normalized fEPSP amplitude relative to the amplitude of the first fEPSP. *p < 0.05. C, Strongly reduced frequency facilitation induced by continuous stimulation at 1 Hz for 1 min in pro-aggregant mice. fEPSP amplitude were normalized to baseline value obtained at 0.1 Hz. Only partial recovery was observed in the pro-aggregant-OFF group. Inset, Individual fEPSPs from a control slice before and during frequency facilitation recorded at the same time points as in the normalized diagram. D, Reduction of frequency facilitation in anti-aggregant mice was reversed in the anti-aggregant-OFF group.