Figure 8.
Cessation of pro-aggregant TauRD expression reverses the decrease of PTP and LTP at the mossy fiber–CA3 synapse. A, B, Characteristic time course of fEPSP changes after an LTP-inducing stimulation protocol in a control slice and in a slice from pro-aggregant TauRD mice. Traces above the diagram depict individual fEPSPs taken before induction of LTP, 25 min after induction and in the presence of DCG IV. C, The summary diagram demonstrates the complete reversal of LTP suppression in the pro-aggregant-OFF group. D, Impaired PTP in slices of the anti-aggregant group is reversed after switch-OFF. mf, Mossy fiber.