Table 1.

Neuromotor measures

	PRO		CTRL		ANTI
	ON	OFF	ON	OFF	ON	OFF
Grip strength (mN)
10 months
Mean	760		758		756
Last trial	754		753		789
14 months
Mean	783	793	799	764	775	793
Last trial	881	817	870	729	900	954
Rotarod (s, on rod)
10 months
Mean	173*		232		209
Last trial	254		270		262
14 months
Mean	227	211	228	201	208	190
Last trial	276	279	270	300	283	300
Activity (number of beam crossings)
10 months	13,151		12,979		15,601
14 months	8717	9605	7929	8562	7904	9475

There are only minor differences in motoric measures between transgenic and nontransgenic mice. Grip strength (in millinewtons) expressed as the mean of 10 successive trials did not differ between three groups (PRO, pro-aggregant; CTRL, control; ANTI, anti-aggregant). On the accelerating rotarod, all groups showed a learning curve across the four consecutive trials. Although pro-aggregant Tau_RD mice started with a lower performance (*p < 0.01), all groups showed a similar performance on the last trial. Also, total counts during a 23 h recording yielded approximately the same number of beam crossings for all three groups in the home cage activity (p > 0.05 for all comparisons). After switching off half of the mice in each group, no motor differences became noticeable (p > 0.05 for all comparisons).