Table 5.

Brain regions showing an interaction effect between capsaicin and coughing

Region	Positive interaction				Region	Negative interaction
	Peak voxel coordinate			Z score		Peak voxel coordinate			Z score
	x	y	z			x	y	z
PMC	−18	−26	62	3.12	PFC	26	50	2	3.91
	22	−22	62	3.21	aMCC	−2	24	32	3.05
	60	−2	38	3.22		2	26	32	3.39
M1	−18	−26	58	3.54	SMA	0	0	66	3.97
	6	−36	58	3.48	SFG	4	26	56	3.78
SM	62	−12	30	3.47	aINS	42	16	0	3.18
S2	−44	−32	22	3.26	IFG	42	28	−4	3.26
	48	−26	24	3.04
pINS	−32	−26	14	3.58
	38	−32	14	3.22
pMCC	−8	−12	36	4.03
	8	−10	38	4.15
PCC	−8	−32	42	3.87
	12	−26	38	3.56

The coordinates of maximally activated voxels are given in MNI space where x, y, and z coordinates represent the medial-lateral, anterior-posterior, and superior-inferior distances (in millimeters) from the anterior commissure. SMA, Supplementary motor area; PMC, premotor cortex; M1, primary motor cortex; SFG, superior frontal gyrus; PFC, prefrontal cortex; aMCC, anterior mid cingulate cortex; pMCC, posterior mid-cingulate cortex; SM, primary somatosensory/motor cortex; S2, secondary somatosensory cortex; aINS, anterior insula; pINS, posterior insula; PCC, posterior cingulate cortex; IFG, inferior frontal gyrus.

All activations identified at cluster-level significance of p < 0.05 (corrected).