Figure 7.

Class IV sensory system organization through Mirr shapes a nociceptive response. A–C, Bar charts indicating the percentage of animals that elicit a rolling response within a 20 s period. WT (A), mirr reduction of function (B), and ectopic expression of mirr (C) in the SOP lineages. C, Ectopic expression of mirr in the SOP lineages leads to a greatly increased sensitivity to a noxious thermal probe applied to the lateral body wall. Furthermore, in WT the initiation of the rolling response is in an anticlockwise direction (blue); however, in manipulated larva the response is often initiated in a clockwise direction (red).