Figure 6.

UCM765 in vivo enhanced the firing rate and rhythmic burst activity of Rt neurons. A, Single-neuron activity recording (first trace), with integrated histogram of spontaneous firing rate (second trace), burst event (third trace), and burst instantaneous frequency (fourth trace) after injection of vehicle or UCM765 (20 mg/kg, i.v.). Arrows indicate the start of injection. The time scale (20 s) applies to all four traces. B, Plot of mean interspike intervals (in milliseconds) against the number of spikes per burst, for 3 min in the basal condition and immediately after the intravenous injection of vehicle or UCM765. The mean from eight neurons (1 neuron per rat) is shown. C, Typical waveform of Rt neurons. Top insets, Amplification of recordings after vehicle and UCM765 injections, visualizing the typical accelerando-decelerando pattern of Rt neurons characterized by an initial part with frequency acceleration (200–250Hz) and deceleration, followed by long-lasting tonic barrage of spikes of ∼100 Hz (tail). Note that after UCM765 injection, the number of spikes per burst increases. Time scale, 50 ms.