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. 2011 Dec 14;31(50):18381–18390. doi: 10.1523/JNEUROSCI.3386-11.2011

Figure 8.

Figure 8.

Density and kinetic properties of Nav1.8 currents in medium-sized sensory neurons. A, B, CCL2 increases the maximal peak current amplitude of Nav1.8 (***p < 0.001, CCL2 alone vs control). The activation of Nav1.8 currents induced by CCL2 is inhibited after treatment with INCB3344 (###p < 0.001 compared with CCL2 alone; Student's t test). C, No change in the steady-state inactivation curve of Nav1.8 was seen following CCL2 treatment (n = 6–11). D, E, Both PTX and gallein reverse CCL2-induced Nav1.8 current activation (#p < 0.05 and ###p < 0.001 compared with CCL2 alone, respectively). Half-maximal potentials (V1/2) and slope (k) values are reported in Table 2. Error bars indicate SEM.