Figure 7.

Disc1 mutant mice had lower spine density in frontal cortical and hippocampal pyramidal neurons. A, High magnification (100×) of Golgi-stained images of spine protrusions on apical dendrites. Scale bar, 5 μm. Note the arrows indicating clear dendritic spines. B, Quantification of spine density (number of spines/μm) in all groups showed a significant lower density in mutant mice when compared to WT in frontal cortex and hippocampus (frontal cortex, n = 30; hippocampus, n = 26–33; t test, p < 0.01). All data are presented as mean ± SEM; **p < 0.01 versus WT.