Table 3.
Performance of different versions of the cirrhosis status algorithm
| Time post-HCC diagnosis/days | Algorithm 1 No ascites - ALD - AHF |
Algorithm 2 No ascites +ALD + AHF |
Algorithm 3 Ascites +ALD + AHF |
Algorithm 4 Pre-HCC ascites +ALD + AHF |
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| Sens | 95% CI | Spec | 95% CI | Sens | 95% CI | Spec | 95% CI | Sens | 95% CI | Spec | 95% CI | Sens | 95% CI | Spec | 95% CI | |
| 0 | 0.45 | 0.39 to 0.51 | 1.00 | 1.00 to 1.00 | 0.47 | 0.41 to 0.52 | 1.00 | 1.00 to 1.00 | 0.49 | 0.43 to 0.54 | 1.00 | 1.00 to 1.00 | 0.49 | 0.43 to 0.54 | 1.00 | 1.00 to 1.00 |
| 30 | 0.52 | 0.47 to 0.58 | 1.00 | 1.00 to 1.00 | 0.54 | 0.49 to 0.60 | 1.00 | 1.00 to 1.00 | 0.57 | 0.51 to 0.63 | 0.99 | 0.98 to 1.00 | 0.57 | 0.51 to 0.63 | 1.00 | 1.00 to 1.00 |
| 60 | 0.60 | 0.55 to 0.66 | 1.00 | 1.00 to 1.00 | 0.64 | 0.58 to 0.69 | 1.00 | 1.00 to 1.00 | 0.66 | 0.61 to 0.72 | 0.98 | 0.96 to 1.00 | 0.66 | 0.61 to 0.71 | 1.00 | 1.00 to 1.00 |
| 90 | 0.66 | 0.61 to 0.72 | 1.00 | 1.00 to 1.00 | 0.70 | 0.65 to 0.75 | 1.00 | 1.00 to 1.00 | 0.73 | 0.68 to 0.78 | 0.97 | 0.95 to 0.99 | 0.72 | 0.67 to 0.77 | 1.00 | 1.00 to 1.00 |
| 120 | 0.69 | 0.64 to 0.74 | 1.00 | 1.00 to 1.00 | 0.73 | 0.68 to 0.78 | 1.00 | 1.00 to 1.00 | 0.75 | 0.70 to 0.80 | 0.97 | 0.95 to 0.99 | 0.75 | 0.70 to 0.80 | 1.00 | 1.00 to 1.00 |
| 150 | 0.72 | 0.67 to 0.77 | 1.00 | 1.00 to 1.00 | 0.76 | 0.72 to 0.81 | 1.00 | 1.00 to 1.00 | 0.79 | 0.74 to 0.83 | 0.96 | 0.94 to 0.98 | 0.78 | 0.73 to 0.83 | 1.00 | 1.00 to 1.00 |
| 180 | 0.73 | 0.68 to 0.78 | 0.99 | 0.98 to 1.00 | 0.77 | 0.73 to 0.82 | 0.99 | 0.98 to 1.00 | 0.80 | 0.75 to 0.84 | 0.95 | 0.92 to 0.97 | 0.79 | 0.74 to 0.84 | 0.99 | 0.98 to 1.00 |
| 365 | 0.76 | 0.71 to 0.81 | 0.99 | 0.98 to 1.00 | 0.81 | 0.76 to 0.85 | 0.99 | 0.98 to 1.00 | 0.83 | 0.78 to 0.87 | 0.94 | 0.91 to 0.97 | 0.82 | 0.78 to 0.87 | 0.99 | 0.98 to 1.00 |
| 730 | 0.80 | 0.76 to 0.85 | 0.98 | 0.96 to 1.00 | 0.84 | 0.80 to 0.88 | 0.98 | 0.96 to 1.00 | 0.87 | 0.83 to 0.91 | 0.95 | 0.93 to 0.98 | 0.85 | 0.81 to 0.89 | 0.98 | 0.96 to 1.00 |
| 1095 | 0.81 | 0.77 to 0.86 | 0.98 | 0.96 to 1.00 | 0.85 | 0.81 to 0.89 | 0.98 | 0.96 to 1.00 | 0.88 | 0.84 to 0.92 | 0.92 | 0.89 to 0.95 | 0.86 | 0.82 to 0.90 | 0.98 | 0.96 to 1.00 |
| Total follow-up | 0.81 | 0.77 to 0.86 | 0.98 | 0.96 to 1.00 | 0.85 | 0.81 to 0.89 | 0.98 | 0.96 to 1.00 | 0.88 | 0.84 to 0.92 | 0.92 | 0.89 to 0.95 | 0.86 | 0.82 to 0.90 | 0.98 | 0.96 to 1.00 |
ALD, alcoholic liver disease; AHF, alcoholic hepatic failure; HCC, hepatocellular carcinoma; Spec, specificity; Sens, sensitivity.