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. 2019 Jul 10;9(7):e024377. doi: 10.1136/bmjopen-2018-024377

Table 2.

Factors associated with occurrence of drug-related problems in neonatal intensive care

Variables Univariate analysis Multivariate analysis
OR 95% CI P value AOR 95% CI P value
Collected at patient admission
  Gestational age in weeks 0.87 0.83 to 0.91 <0.001 0.85 0.81 to 0.89 0.003
  Female sex 1.32 0.94 to 1.84 0.105
  Birth weight (kg) 0.55 0.46 to 0.68 <0.001
  Vaginal delivery 1.49 1.10 to 2.12 0.025
  PROM 1.21 0.83 to 1.78 0.322
  1 min Apgar <7 1.49 1.06 to 2.08 0.020
  5 min Apgar <7 2.03 1.18 to 3.48 0.010 1.74 1.00 to 3.13 0.050
  Neurological disorder 2.12 1.09 to 4.17 0.028 2.49 1.09 to 5.69 0.031
  Renal disorder 8.90 3.17 to 25.04 <0.001 5.75 1.85 to 17.8 0.002
  Cardiac disorder 2.08 1.31 to 3.32 <0.001 2.36 1.31 to 4.24 0.004
  Malformations 1.35 0.79 to 2.29 0.267
Collected at NICU discharge
  Number of unique medications 1.36 1.28 to 1.44 <0.001 1.22 1.13 to 1.32 <0.001
  Length of stay in days 1.08 1.06 to 1.10 <0.001 1.04 1.02 to 1.06 <0.001
  Number of clinical problems 1.60 1.44 to 1.77 <0.001 1.22 1.13 to 1.32 <0.001

AOR, adjusted OR; NICU, neonatal intensive care unit; PROM, premature rupture of membranes.