Table 2.
Factors associated with occurrence of drug-related problems in neonatal intensive care
| Variables | Univariate analysis | Multivariate analysis | ||||
| OR | 95% CI | P value | AOR | 95% CI | P value | |
| Collected at patient admission | ||||||
| Gestational age in weeks | 0.87 | 0.83 to 0.91 | <0.001 | 0.85 | 0.81 to 0.89 | 0.003 |
| Female sex | 1.32 | 0.94 to 1.84 | 0.105 | |||
| Birth weight (kg) | 0.55 | 0.46 to 0.68 | <0.001 | |||
| Vaginal delivery | 1.49 | 1.10 to 2.12 | 0.025 | |||
| PROM | 1.21 | 0.83 to 1.78 | 0.322 | |||
| 1 min Apgar <7 | 1.49 | 1.06 to 2.08 | 0.020 | |||
| 5 min Apgar <7 | 2.03 | 1.18 to 3.48 | 0.010 | 1.74 | 1.00 to 3.13 | 0.050 |
| Neurological disorder | 2.12 | 1.09 to 4.17 | 0.028 | 2.49 | 1.09 to 5.69 | 0.031 |
| Renal disorder | 8.90 | 3.17 to 25.04 | <0.001 | 5.75 | 1.85 to 17.8 | 0.002 |
| Cardiac disorder | 2.08 | 1.31 to 3.32 | <0.001 | 2.36 | 1.31 to 4.24 | 0.004 |
| Malformations | 1.35 | 0.79 to 2.29 | 0.267 | |||
| Collected at NICU discharge | ||||||
| Number of unique medications | 1.36 | 1.28 to 1.44 | <0.001 | 1.22 | 1.13 to 1.32 | <0.001 |
| Length of stay in days | 1.08 | 1.06 to 1.10 | <0.001 | 1.04 | 1.02 to 1.06 | <0.001 |
| Number of clinical problems | 1.60 | 1.44 to 1.77 | <0.001 | 1.22 | 1.13 to 1.32 | <0.001 |
AOR, adjusted OR; NICU, neonatal intensive care unit; PROM, premature rupture of membranes.