Table 1:
Demographics and Admission Values as Stratified by Operational Definitions of Osteomyelitis
| Factor | Traditional Histology | Traditional Culture | Genetic Sequencing |
|---|---|---|---|
| Osteomyelitis diagnosis, % (n) | 45.7 (16) | 68.6 (24) | 82.9 (29) |
| Male sex, % (n) | 67.8 (11) | 70.8 (17) | 75.9 (22) |
| Median age, y | 44.5 (13) | 45.5 (16) | 46.0 (17) |
| Body mass index >30 kg/m2, % (n) | 37.5 (6) | 50.0 (12) | 37.9 (11) |
| Type 2 diabetes mellitus, % (n) | 81.3 (13) | 87.5 (21) | 86.2 (25) |
| Glycated hemoglobin >10%, % (n) | 31.3 (5) | 41.7 (10) | 48.3 (14) |
| Any history of tobacco use, % (n) | 56.3 (9) | 58.3 (14) | 58.6 (17) |
| History of diabetic foot ulceration, % (n) | 81.3 (13) | 70.8 (17) | 65.5 (19) |
| Vibrotactile perception threshold >25 Hz, % (n) | 75.0 (12) | 79.2 (19) | 79.3 (23) |
| Ankle-brachial index <0.9, % (n) | 18.8 (3) | 20.8 (5) | 24.1 (7) |
| Median ankle—brachial index | 1.1 (0.2) | 1.08 (0.2) | 1.07 (0.2) |
| SPP great toe, mm Hg | 57.0 (58) | 69.0 (60) | 74.0 (54) |
| SPP plantar medial forefoot, mm Hg | 75.5 (23) | 76.5 (28) | 77.0 (23) |
| SPP plantar lateral forefoot, mm Hg | 90.5 (53) | 88.5 (42) | 86.0 (47) |
| SPP dorsal foot, mm Hg* | 94.5 (62) | 80.0 (74) | 87.0 (62) |
| White blood cell count on admission, × 109/L | 8.4 (5.9) | 6.7 (5.7) | 7.3 (6.5) |
| Erythrocyte sedimentation rate on admission, mm/h* | 97.5 (74) | 67.5 (70) | 70.0 (69) |
| C-reactive protein on admission, mg/dL | 7.5 (12.8) | 7.0 (12.3) | 7.7 (12.6) |
*
Significant trend based on alpha ≤0.05.