Table 2.

The four treatment sequences (TS’s) embedded in the SMART study design (Figure 1)

Embedded Treatment sequences (TS)	Initial treatment	Subsequent tactic (treatment) for non-responders	Subsequent tactic for responders	Subgroups in Figure 1
1	APP	Modest Step-Up (APP+T)	Continue first-line intervention	B+C
2	APP	Vigorous Step-Up (APP+T+C)		A+C
3	APP + C	Modest Step-Up (APP + C+T)		E+F
4	APP + C	Vigorous Step-Up (APP + C+T+MR)		D+F