Figure 6:
Extracellular volume (ECV) increased (A) and the intracellular lifetime of water (τic) declined (B) after anthracycline. The p values in A and B are for the fixed effect of follow-up time (in quartiles) versus baseline in linear mixed-effects models for ECV and τic respectively. (From Ferreira de Souza T, Quinaglia A C Silva T, Osorio Costa F, et al. Anthracycline Therapy Is Associated With Cardiomyocyte Atrophy and Preclinical Manifestations of Heart Disease. JACC Cardiovasc Imaging. 2018 Aug;11(8):1045–1055; with permission).