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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Trends Pharmacol Sci. 2019 Apr 5;40(5):309–326. doi: 10.1016/j.tips.2019.03.004

Figure 1.

Figure 1

(A) Plants constitute the best source of nature-derived GPCR ligands. (B) Taste 2, aminergic, as well as opioid and cannabinoid GPCRs are leading targets of natural products. (C) Trend in discovery of small molecules (524) versus peptides (104) as nature-derived GPCR ligands from 1980 to 2018. Ligands before 1980 were not included.