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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Lancet Infect Dis. 2015 Aug 4;15(10):1156–1166. doi: 10.1016/S1473-3099(15)00154-1

Figure 4. Cutaneous vasculitis after rVSV-ZEBOV immunisation.

Figure 4

Purpuric lesions on the pretibial area (A) and lower legs (D) of two vaccinees. Haematoxylin and eosin stain (original magnification × 2) shows swollen endothelial cells and a dense perivascular lymphocytic infiltrate with numerous extravasated erythrocytes, but no fibrinoid necrosis or thrombi (B, E). Examination of skin biopsy samples were done on days 2 and 5 after the onset of purpura, respectively. Immunostaining identifies the lymphocytic infiltrate as composed mainly of CD4+ T cells (C, F). Complement C3 was detected in the vessel walls and at the dermal epidermal junction (not shown), without IgG, IgM, or IgA deposits. rVSV-ZEBOV=recombinant vesicular stomatitis virus-based Zaire Ebola virus vaccine.